Systems and methods for single-molecule detection using nanopores
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJacob Rosenstein, Kenneth L. Shepard
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Abstract
A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any.
Claims20
A method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof, comprising:
- passing a target molecule through the nanopore;
- and
- measuring a current through the nanopore to detect the presence of a biomolecular entity, if any,
- wherein the first reservoir is adjacent a first side of the preamplifier and the second reservoir is adjacent an opposing second side of the preamplifier.
An integrated circuit for single-molecule detection, comprising:
- at least one membrane having a nanopore located between first and second reservoirs;
- a low-noise preamplifier for measuring the change in pore current upon passing a target entity through the nanopore, the first reservoir adjacent a first side of the preamplifier and the second reservoir adjacent an opposing second side of the preamplifier, wherein the preamplifier has at least one electrode formed on the surface thereof.
Dependencies are inferred from the claim text.