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US 9,217,701 B2Granted
Biomarker normalization
AssigneeThe Regents of the University of California
InventorBenjamin Sullivan
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Abstract
A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.
Claims42
A fluid measuring system comprising:
- a processing device which receives a sample chip configured to contain an aliquot volume of a sample fluid,
- wherein the processing device is configured to perform analyses of
- (a) the osmolarity of the sample fluid, and
- (b) at least one biomarker within the sample fluid selected from:
- glucose, insulin, a protein, a hormone, a hormone metabolite, a nucleic acid, a lipid fraction, or any combination thereof;
- wherein the analysis of the one or more biomarkers includes normalization of biomarker concentration values.
3 more elements
A method of measuring a sample fluid, the method comprising:
- (a) receiving an output signal from a sample region of a sample chip that is configured to produce an osmolarity output signal that correlates to the osmolarity of the sample fluid;
- (b) receiving an output signal from the sample region of the sample chip that is configured to produce a biomarker output signal that correlates to the concentration values for one or more biomarkers selected from:
- glucose, insulin, a protein, a hormone, a hormone metabolite, a nucleic acid, a lipid fraction, or any combination thereof;
- (c) processing (i) the osmolarity output signal to produce an osmolarity value for the sample fluid, and (ii) the biomarker output signal to produce a biomarker concentration value for the sample fluid;
- and
- (d) determining an Adjusted Biomarker Level that provides normalization of biomarker concentration values.
3 more elements
Dependencies are inferred from the claim text.