Chimeric Newcastle disease viruses and uses thereof
AssigneesIcahn School of Medicine at Mount Sinai, Memorial Sloan Kettering Cancer Center
InventorsPeter Palese, Adolfo Garcia-Sastre, Dmitriy Zamarin, Yuman Fong
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Abstract
Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.
Claims14
A chimeric Newcastle disease virus (NIV), comprising a packaged genome which encodes a heterologous interferon antagonist and a modified F protein with a mutated cleavage site, wherein the heterologous interferon antagonist and the modified F protein are expressed by the virus.
Dependencies are inferred from the claim text.