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US 9,212,217 B2Granted
Antibody molecules to dengue virus and uses thereof
AssigneeVisterra, Inc.
InventorsLuke Robinson, Zachary Shriver, James Myette, Gregory Babcock, Karthik Viswanathan
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Abstract
Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus.
Claims21
An isolated antibody molecule capable of binding dengue virus, comprising:
- (a) a heavy chain immunoglobulin variable region segment comprising:
- a CDR1 comprising the sequence DVYMS (SEQ ID NO:
- 3),
- a CDR2 comprising the sequence RIDPENGDTKYDPKLQG (SEQ ID NO:
- 4), and
- a CDR3 comprising the sequence GWEGFAY (SEQ ID NO:
- 5);
- and
- (b) a light chain immunoglobulin variable region segment comprising:
- a CDR1 comprising the sequence RASENVDKYGNSFMH (SEQ ID NO:
- 6),
- a CDR2 comprising the sequence RASELQW (SEQ ID NO:
- 7), and
- a CDR3 comprising the sequence QRSNEVPWT (SEQ ID NO:
- 8).
12 more elements
Dependencies are inferred from the claim text.