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US 9,212,120 B2Granted
Process for preparing spiro[2.5]octane-5,7-dione
AssigneeBoehringer Ingelheim International GmbH
InventorsTorsten Busch, Sven Anklam, Joerg Jung, Markus Ostermeier
Life of this patent
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Abstract
Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound.
Claims3
A method of preparing spiro[2.5]octane-5,7-dione having the formula
- said method comprising cyclizing a [1-(2-oxo-propyl)-cyclopropyl]-acetic acid ester, having the formula
- wherein R is C1-C6 alkyl, by subjecting the [1-(2-oxo-propyl)-cyclopropyl]-acetic acid ester to condensation conditions using a suitable base in a suitable solvent at a suitable reaction temperature for cyclization to form spiro[2.5]octane-5,7-dione.
Dependencies are inferred from the claim text.