Compositions and methods of treating metabolic disorders
AssigneeElcelyx Therapeutics, Inc.
InventorsAlain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
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Abstract
Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
Claims8
A method of treating a renally impaired subject having diabetes, comprising administering a therapeutically effective amount of metformin or a salt thereof to said subject in a formulation targeted for delivery to the distal small intestine, wherein said formulation comprises an oral dosage form enterically coated at a pH at or above 6.0 or 6.5, and wherein the metformin has a reduced relative average bioavailability of about 40, 50 or 60% in said formulation in comparison with an immediate-release formulation having the same amount of metformin or salt thereof.
Dependencies are inferred from the claim text.