Viral vector encoding a toll-like receptor and encoding a toll-like receptor agonist
AssigneePanacela Labs, Inc.
InventorAndrei V. Gudkov
Life of this patent
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Abstract
The present invention is directed to methods and agents used for treating cancer or infectious diseases by providing toll-like receptors such as toll-like receptor 5 (TLR-5) in combination with providing a toll-like receptor agonists such as flagellin resulting in a cis and in-trans effect that recruits cells involved in both the innate (cis effect) and adaptive (trans effect) immune response to specifically kill cancer cells and cells infected with a pathogen via the NF-κB apoptosis pathway.
Claims20
A vector comprising a first and second nucleic acid, wherein the first nucleic acid encodes a toll-like receptor and the second nucleic acid encodes a toll-like receptor agonist selected from the group consisting of a heat shock protein, HMGB1 (high mobility group box 1-amphoterin), fibrinogen, fibronectin, RSV fusion protein, MMTV (mouse mammary tumor virus) envelope protein, flagellin and profilin.
Dependencies are inferred from the claim text.