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US 9,205,035 B2Granted
Ion substituted calcium phosphate particles
AssigneePsilox AB
InventorsHakan Engqvist, Wei Xia
Life of this patent
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Abstract
A method for formation of spherical particles of ion substituted calcium phosphate. The method is based on precipitation of particles from a buffered solution under static, stirring or hydrothermal conditions. Also, the use of the formed materials and the particles in itself.
Claims17
A method for the formation of substantially spherical particles of an ion substituted calcium phosphate compound, comprising the steps of:
- providing an aqueous solution comprising calcium, magnesium and phosphate ions, and one or more of sodium, potassium, chloride, carbonate or sulphate ions,
- wherein the concentration of said ions are:
- calcium ions in the range of 0.01-25×10−3 M, magnesium ions in the range of 0.01-15×10−3 M, and phosphate ions in the range of 0.01-10×10−3 M,
- and when present, sodium ions in the range of 0.01-1420×10−3 M, potassium ions in the range of 0.01-1420×10−3 M, chloride ions in the range of 0.01-1030×10−3 M, carbonate ions in the range of 0.01-270×10−3 M, and sulphate ions in the range of 0.01-5×10−3 M,
- wherein the solution has an initial pH in the range of 2.0 to 10.0, and
- wherein the solution further comprises at least one of substitution ions Sr2+, F−or Si4+;
- and
- precipitating the particles by a self-organized process in a solution according to a, b, c, d or e, wherein:
- a. is a static process wherein the solution comprises Sr2 +in a concentration of 0.15 mM to 0.6 mM, and wherein the solution has a temperature in the range of 37-60° C. to give spherical hollow particles,
- b. is a stirring process wherein the solution comprises Sr2+in a concentration of 0.15 mM to 0.67 mM, and wherein the solution has a temperature in the range of 37-60° C. to give spherical hollow particles,
- c. is a hydrothermal process wherein the solution comprises Sr2+in a concentration of 0.3 mM to 0.67 mM, and wherein the process is performed at a temperature range of 60° C. to 100° C. to give spherical particles with a dense shell and a porous core;
- d. is a hydrothermal process wherein the solution comprises F−in a concentration of 0.04 mM to 0.22 mM, and wherein the process is performed between 80° C. and 100° C. to give spherical porous particles;
- and
- e. is a hydrothermal process wherein the solution comprises Si4+in a concentration of 6 mM to 10 mM, and wherein the process is performed between 80° C. and 100° C. to give spherical porous particles.
11 more elements
A particle obtained by a method for the formati of substantially spherical particles of an ion substituted calcium phosphate compound, the method comprising the steps of:
- providing an aqueous solution comprising calcium, magnesium and phosphate ions, and one or more of sodium, potassium, chloride, carbonate or sulphate ions,
- wherein the concentration of said ions are:
- calcium ions in the range of 0.01-25×10−3 M, magnesium ions in the range of 0.01-15×10−3 M, and phosphate ions in the range of 0.01-10×10−3 M,
- and when present, sodium ions in the range of 0.01-1420×10−3 M, potassium ions in the range of 0.01-1420×10−3 M, chloride ions in the range of 0.01-1030×10−3 M, carbonate ions in the range of 0.01-270×10−3 M, and sulphate ions in the range of 0.01-5×10−3M,
- wherein the solution has an initial pH in the range of 2.0 to 10.0, and
- wherein the solution further comprises one of the substitution ions Sr2+, F−or Si4+;
- and
- precipitating the particles by a self-organized process in a solution according to a, b, c, d or e wherein:
- a. is a static process wherein the solution comprises Sr2+in a concentration of 0.15 mM to 0.6 mM, and wherein the solution has a temperature in the range of 37-60° C. to give spherical hollow particles,
- b. is a stirring process wherein the solution comprises Sr2+in a concentration of 0.15 mM to 0.67 mM, and wherein the solution has a temperature in the range of 37-60° C. to give spherical hollow particles,
- c. is a hydrothermal process wherein the solution comprises Sr2+in a concentration of 0.3 mM to 0.67 mM, and wherein the process is performed at a temperature range of 60° C. to 100° C. to give spherical particles with a dense shell and a porous core;
- d. is a hydrothermal process wherein the solution comprises F−in a concentration of 0.04 mM to 0.22 mM, and wherein the process is performed between 80° C. and 100° C. to give spherical porous particles;
- and
- e. is a hydrothermal process wherein the solution comprises Si4+in a concentration of 6 mM to 10 mM, and wherein the process is performed between 80° C. and 100° C. to give spherical porous particles.
11 more elements
Dependencies are inferred from the claim text.