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US 9,200,324 B2Granted
Biomarkers and methods for measuring and monitoring inflammatory disease activity
AssigneesCrescendo Bioscience, Inc., Oklahoma Medical Research Foundation
InventorsGuy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
Life of this patent
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Abstract
Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
Claims4
A method for generating quantitative data for a first subject comprising:
- performing at least one immunoassay on a first sample from the first subject to generate a first dataset comprising the quantitative data, wherein the quantitative data represents at least twelve protein markers comprising:
- chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1);
- C-reactive protein, pentraxin-related (CRP);
- epidermal growth factor (beta-urogastrone) (EGF);
- interleukin 6 (interferon, beta 2) (IL6);
- leptin (LEP);
- matrix metallopeptidase 1 (interstitial collagenase) (MMP1);
- matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3);
- resistin (RETN);
- serum amyloid A1 (SAA1);
- tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A);
- vascular cell adhesion molecule 1 (VCAM1);
- and, vascular endothelial growth factor A (VEGFA);
- and
- wherein the first subject has rheumatoid arthritis (RA) or is suspected of having RA.
12 more elements
Dependencies are inferred from the claim text.