Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i
AssigneeMorpho Sys AG
InventorsMichael Tesar, Ute Jaeger
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
Claims15
A method for treating a hematologic cancer associated with the undesired presence of CD38+ cells comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated human or humanized antibody or functional fragment thereof specific for CD38 wherein said antibody or fragment thereof binds an epitope of CD38 that contains one or more amino acid residues within 192-206 of SEQ ID NO:
- 22 and a pharmaceutically acceptable carrier or excipient.
A method for treating a hematologic cancer associated with the undesired presence of CD38+ cells comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated human or humanized antibody or functional fragment thereof specific for CD38 wherein said antibody or fragment thereof binds an epitope of CD38 that contains one or more amino acid residues within 44-66, 110-122, 148-164, 186-200, and 202-224 of SEQ ID NO:
- 22 and a pharmaceutically acceptable carrier or excipient.
A method for treating a hematologic cancer associated with the undesired presence of CD38+ cells comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated human or humanized antibody or functional fragment thereof specific for CD38 wherein said antibody or fragment thereof binds an epitope of CD38 that contains one or more amino acid residues within 82-94 and 158-170 of SEQ ID NO:
- 22 and a pharmaceutically acceptable carrier or excipient.
A The method for treating a hematologic cancer associated with the undesired presence of CD38+ cells comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated human or humanized antibody or functional fragment thereof specific for CD38 wherein said antibody or fragment thereof binds an epitope of CD38 that contains one or more amino acid residues within 82-94, 142-154, 158-170, 188-200, and 280-296 of SEQ ID NO:
- 22 and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.