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US 9,199,897 B2Granted
Methods for preparing squalene
AssigneeNovartis AG
InventorManinder Hora
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Abstract
An improved method for preparing squalene from a squalene-containing composition, said method comprising the steps of (a) a purification distillation carried out at a temperature T1; (b) a denaturing distillation carried out at a temperature T2; wherein steps (a) and (b) may be performed in either order; T1 and T2 are sufficient to cause squalene to boil; T2>T1; and T2>200° C.
Claims13
A method for manufacturing squalene suitable for pharmaceutical use in a vaccine which comprises subjecting fish oil comprising squalene to:
- (i) a purification distillation carried out at near vacuum;
- and
- (ii) a denaturing distillation carried out at a temperature greater than or equal to 210° C. at a pressure of 0.8 to 5.0 mmHg, wherein the temperature in the denaturing distillation exceeds the temperature in the purification distillation;
- and
- wherein the conditions for both the purification distillation and the denaturing distillation are sufficient to cause the squalene to boil;
- and
- wherein the denaturing distillation denatures and/or removes potential contaminant proteins and viruses, thereby rendering the squalene safer for human use as compared with non-denatured squalene.
4 more elements
Dependencies are inferred from the claim text.