Drug-eluting rotational spun coatings and methods of use
AssigneeMerit Medical Systems, Inc.
InventorsJohn William Hall, Rachel L. Simmons, Aaron Hopkinson, Bart Dolmatch, Zeke Eller, Robert S. Kellar
Life of this patent
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Abstract
Drug-eluting rotational spun coatings that include one or more therapeutic agents may be used to coat a medical device. The medical devices include, for example, balloon catheters, vascular grafts and stents, which are coated with drug-eluting rotational spun materials that may be used to deliver a therapeutic agent to a target tissue or body lumen.
Claims33
A medical device comprising a drug-eluting rotational spun coating, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the drug-eluting rotational spun coating is configured to provide a controlled release of the therapeutic agent to the target issue in approximately 5 minutes or less, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
A medical device comprising a drug-eluting rotational spun coating and at least one layer of non-spun material, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
A medical device comprising a drug-eluting rotational spun coating, wherein the drug-eluting rotational spun coating comprises a therapeutic agent in an amount configured to deliver a pharmaceutically effective dose to a target tissue, wherein the therapeutic agent is associated with the drug-eluting rotational spun coating via covalent or ionic bonding, wherein the drug-eluting rotational spun coating comprises at least two layers of rotational spun fibers having a diameter of between about 50 nanometers and about 3 micrometers, and wherein the drug-eluting rotational spun coating has a percent porosity of between about 30% and about 80%.
Dependencies are inferred from the claim text.