Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases

A polypeptide comprising an amino acid sequence with the general structure FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4 in which FR1-FR4 refer to framework regions 1 to 4, respectively, and in which CDR1 to CDR3 refer to the complementary determining regions 1 to 3 respectively that specifically binds to an F protein of a respiratory syncytial virus (RSV), wherein the polypeptide comprises a combination of CDR1, CDR2, and CDR3 selected from (a), (b), (c), (d), (e), or (f):

• (a) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 723;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 723;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 723;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1287;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1287;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1287;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1851;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1851;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1851;
• (b) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:731;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 731;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference the amino acid sequence of SEQ ID NO:
• 731;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1295;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1295;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference the amino acid sequence of SEQ ID NO:
• 1295;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1859;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1859;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1859;
• (c) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 918;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 918;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 918;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1482;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1482;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1482;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2046;
• 2. amino acid sequences that have at least 80% amino acid identity the amino acid sequence of SEQ ID NO:
• 2046;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 2046;
• (d) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 935;
• 2. amino acid sequences that have at least 80% amino acid identity the amino acid sequence of SEQ ID NO:
• 935;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 935;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1499;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1499;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1499;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2063;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 2063;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 2063;
• (e) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 936;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 936;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference the amino acid sequences of SEQ ID NO:
• 936;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 1500;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 1500;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 1500;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2064;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 2064;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 2064;
• (f) a CDR1 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2595;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 2595;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 2595;
• a CDR2 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2611;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 2611;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference with the amino acid sequence of SEQ ID NO:
• 2611;
• a CDR3 comprising an amino acid selected from the group consisting of:
• 1. the amino acid sequence of SEQ ID NO:
• 2627;
• 2. amino acid sequences that have at least 80% amino acid identity with the amino acid sequence of SEQ ID NO:
• 2627;
• and
• 3. amino acid sequences that have 3, 2, or 1 amino acid difference the amino acid sequence of SEQ ID NO:
• 2627.