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US 9,187,544 B2Granted
Peptide modulators of angiogenesis and use thereof
AssigneeThe Johns Hopkins University
InventorsAleksander S. Popel, Emmanouil D. Karagiannis
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Abstract
Compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators, are described. As described in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
Claims7
An isolated peptide or analog thereof consisting of a sequence having at least 85% amino acid sequence identity to:
- (SEQ ID NO:
- 2294)
- Chorionic somatomammotropin
- LLRLLLLIESWLE,
- or
- (SEQ ID NO:
- 2295)
- Chorionic somatomammotropin
- LLHISLLLIESRLE
- hormone-like 1
- wherein the peptide reduces blood vessel formation in a cell, tissue, or organ, and comprises at least one modification.
8 more elements
Dependencies are inferred from the claim text.