Stable silk protein fragment compositions
AssigneeSilk Therapeutics, Inc.
InventorsGregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
Life of this patent
Estimating the term…
Abstract
A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
Claims13
A composition comprising:
- pure silk fibroin-based protein fragments having about 0.01% (w/w) to about 10% (w/w) sericin, wherein the fragments have an average weight average molecular weight ranging from 17 kDa to 38 kDa;
- wherein the fragments have a polydispersity of between 1.5 and 3.0;
- wherein the composition is substantially homogeneous;
- wherein the composition includes between 0 ppm to 500 ppm of inorganic residuals;
- wherein the composition includes between 0 ppm to 500 ppm of organic residuals;
- and
- wherein the composition does not spontaneously or gradually gelate and does not visibly change in color or turbidity when in a solution for at least 10 days.
Dependencies are inferred from the claim text.