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US 9,187,534 B2Granted
Multi-epitopic vaccine
AssigneesUniversite De Geneve, Hopitaux Universitaires De Geneve
InventorsMadiha Sabiha Derouazi, Paul R. Walker, Pierre-Yves Dietrich
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Abstract
The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.
Claims14
An isolated polypeptide comprising:
- (i) at least one CD4+ epitope(s);
- (ii) at least one CD8+ epitope(s), wherein said CD4+ and CD8+ epitopes are selected from the group consisting of epitopes from a tumor-associated antigen, epitopes from a tumor-specific antigen, and epitopes from an antigenic protein from a pathogen;
- and
- (iii) a protein transduction domain consisting of SEQ ID NO:
- 8 or a protein transduction domain consisting of amino acids 1 to 43 of SEQ ID NO:
- 8.
3 more elements
Dependencies are inferred from the claim text.