Nitric oxide-releasing nanorods and their methods of use
AssigneeThe University of North Carolina at Chapel Hill
InventorsMark H. Schoenfisch, Yuan Lu
Life of this patent
Estimating the term…
Abstract
In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.
Claims20
A nitric oxide-releasing nanorod comprising,
- i. a silane, and
- ii. a functionalized mono, di or trialkoxysilane,
- wherein said functionalized mono, di or trialkoxysilane comprises a NO-donor molecule;
- wherein said nanorod has an aspect ratio of at least 1 and a [NO]max in a range of about 10 ppb/mg to about 16,000 ppb/mg.
Dependencies are inferred from the claim text.