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US 9,186,380 B2Granted
Minced cartilage systems and methods
AssigneeAlloSource
InventorsYaling Shi, Carolyn Barrett
Life of this patent
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Abstract
Compositions comprising a plurality of cartilage particles from a human adult cadaveric donor, wherein the cartilage particles comprise viable chondrocytes, and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a plurality of cartilage particles from a human adult cadaveric donor are also provided.
Claims18
A method of manufacturing a cartilage composition, the method comprising:
- obtaining cartilage tissue from a human adult cadaveric donor age 15 years or older;
- mincing the cartilage tissue into a plurality of cartilage particles having an average volume from about 1 mm3 to about 30 mm3 using a laser cutter at a power of about 3 Watts to about 13.5 Watts and a frequency of about 400 Hz to about 2400 Hz, wherein the cartilage particles comprise chondrocytes native to the cartilage tissue, and wherein at least 50% of the chondrocytes present in the plurality of cartilage particles are viable;
- suspending the plurality of cartilage particles in a biocompatible carrier;
- and
- packaging the suspended plurality of cartilage particles into a container.
2 more elements
Dependencies are inferred from the claim text.