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US 9,181,632 B1Granted
C.difficile toxin B CROP domain peptides, antibodies and complexes thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsNicholas Murgolo, Lorraine Hernandez, Payal Sheth, Corey Strickland, Peter Orth, Alex Therien, Paul Reichert, Li Xiao
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Abstract
The present invention provides polypeptide domains of C. difficile toxin B (B1, B2, B3, B4) and complexes between the polypeptides and antibodies that bind specifically for the polypeptide. Methods of using the polypeptides to generate antibodies are also provided.
Claims4
An isolated crystal comprising a bezlotoxumab Fab fragment complexed to a polypeptide comprising SEQ ID NO:
- 14, wherein said polypeptide is C. difficile toxin B amino acids 1834-2101 and wherein the crystal is characterized by:
- space group:
- P21;
- and
- unit cell dimensions:
- a=79.413 Å, b=134.659 Å, c=102.579 Å, α=γ=90°, β=112.559°.
3 more elements
Dependencies are inferred from the claim text.