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US 9,181,319 B2Granted
Engineered nucleic acids and methods of use thereof
AssigneeModerna Therapeutics, Inc.
InventorsJason P. Schrum, Stephane Bancel, Noubar B. Afeyan
Life of this patent
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Abstract
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
Claims9
A pharmaceutical formulation comprising:
- i) an effective amount of a messenger ribonucleic acid (mRNA) sequence encoding an insulin polypeptide, wherein the mRNA sequence is at least 95% identical to the sequence of SEQ ID NO:
- 23;
- and
- ii) a pharmaceutically acceptable carrier,
- wherein the formulation is suitable for repeated intravenous administration to a mammalian subject in need thereof.
2 more elements
A pharmaceutical formulation comprising:
- i) an effective amount of an mRNA sequence encoding an insulin polypeptide, wherein the mRNA sequence is at least 95% identical to the sequence of SEQ ID NO:
- 23;
- ii) a cell penetration agent;
- and
- iii) a pharmaceutically acceptable carrier,
- wherein the formulation is suitable for repeated intravenous administration to a mammalian subject in need thereof.
3 more elements
An mRNA sequence encoding an insulin polypeptide, wherein the mRNA sequence is at least 95% identical to the sequence of SEQ ID NO:
- 23.
Dependencies are inferred from the claim text.