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US 9,181,288 B2Granted
Azepane derivatives and methods of treating hepatitis B infections
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Scott Kuduk
Life of this patent
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Abstract
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject. In an embodiment of the compounds provided herein, the compounds are of Formula Va:
Claims6
A compound of Formula Va:
- or a pharmaceutically acceptable salt thereof;
- wherein
- each R1 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl groups are optionally substituted 1-3 times with halo or OH;
- each R2 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl groups are optionally substituted 1-3 times with halo or OH;
- x is 2 or 3;
- Cy is
- and R11 is, independently at each occurrence, —OH, halo, —C1-C6 alkyl, —OC(O)CH3, or —H2PO4, wherein n and m are 1, 2, or 3, and at least one R11 is
4 more elements
Dependencies are inferred from the claim text.