Method and device for separating fractions of a mixture
AssigneeNovasep Process
InventorsEric Valery, Olivier Ludemann-Hombourger
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Abstract
The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23,) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.
Claims30
A method for separating fractions of a mixture to be separated, in a device (1) having:
- several chromatography columns (21, 22, 23, etc.) mounted in series,
- a single separation zone constituted by a constantly open separation loop comprising, at the inlet of the open separation loop an eluent-injection point (6) for injecting eluent into one of the columns and, at the outlet of the open separation loop, a draw-off point (8) for withdrawal of a fraction of the mixture, with no other fluid circulating between the inlet and the outlet of the open separation loop, the method comprising:
- a mixture injection stage for discontinuous injection of the mixture to be separated into the open separation loop (4),
- a collection stage for collection of at least two fractions, and
- a shifting stage for shifting by at least one column the eluent-injection point (6) and the fraction draw-off point (8) of the separation loop (4),
- wherein
- (a) during the shifting stage, the eluent-injection and draw-off points of the separation loop are shifted at different times, or
- (b) said device further comprises at least one other loop, or
- (c) in which the eluent-injection and draw-off points of the separation loop are not contiguous.
A method for separating fractions of a mixture to be separated, in a device (1) having:
- several chromatography columns (21, 22, 23, etc.) mounted in series,
- a single separation zone constituted by a constantly open separation loop comprising, at the inlet of the open separation loop an eluent-injection point (6) for injecting eluent into one of the columns and, at the outlet of the open separation loop, a draw-off point (8) for withdrawal of a fraction of the mixture, the method comprising:
- a mixture injection stage for discontinuous injection of the mixture to be separated into the open separation loop (4),
- a collection stage for collection of at least two fractions, and
- a shifting stage for shifting by at least one column the eluent-injection point (6) and the fraction draw-off point (8) of the separation loop (4);
- wherein said device further comprises at least one desorption loop comprising, at the inlet of the desorption loop, an injection point (46) for injection of eluent into a column of the desorption loop, and, at the outlet of the desorption loop, a draw-off point (48) for withdrawing a fraction of the mixture, and
- wherein the eluents at the inlet of the separation loop and the inlet of said at least one desorption loop have different compositions.
A method for separating fractions of a mixture to be separated, in a device (1) having:
- several chromatography columns (21, 22, 23, etc.) mounted in series,
- a single separation zone constituted by a constantly open separation loop comprising, at the inlet of the open separation loop an eluent-injection point (6) for injecting eluent that is recycled by chosen from the group consisting of distillation, evaporation and the use of membranes into one of the columns and, at the outlet of the open separation loop, a draw-off point (8) for withdrawal of a fraction of the mixture, the method comprising:
- a mixture injection stage for discontinuous injection of the mixture to be separated into the open separation loop (4),
- a collection stage for collection of at least two fractions,
- a shifting stage for shifting by at least one column the eluent-injection point (6) and the fraction draw-off point (8) of the separation loop (4).
Dependencies are inferred from the claim text.