Granzyme A and granzyme B diagnostics
AssigneeThe University of British Columbia
InventorsDavid Granville, Rani Cruz, Ciara Chamberlain, Wendy Boivin, Bruce McManus
Life of this patent
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Abstract
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin.
Claims28
A method of diagnosis of atherosclerosis or coronary artery disease in a subject suspected of having atherosclerosis or coronary artery disease or having atherosclerosis or coronary artery disease, the method comprising:
- a) determining a concentration of Granzyme B (GrB) in a blood plasma or serum sample from said subject;
- and
- b) comparing said concentration to a corresponding concentration in a control sample, wherein an elevated concentration of GrB is indicative of atherosclerosis or coronary artery disease.
A method of diagnosis of chronic inflammatory disease in a subject suspected of having chronic inflammatory disease or having chronic inflammatory disease, the method comprising:
- a) determining a concentration of Granzyme A (GrA) in a blood plasma or serum sample from said subject;
- and
- b) comparing said concentration to a corresponding concentration in a control sample, wherein an elevated concentration of GrA is indicative of chronic inflammatory disease.
A method of diagnosis of a fibrillinopathy in a subject suspected of having fibrillinopathy or having fibrillinopathy, the method comprising:
- a) determining a concentration of (Granzyme A) GrA in a blood plasma or serum sample from said subject;
- and
- b) comparing said concentration to a corresponding concentration in a control sample, wherein an elevated concentration of GrA is indicative of fibrillinopathy.
A method for diagnosis of chronic inflammatory disease in a subject suspected of having chronic inflammatory disease or having chronic inflammatory disease, the method comprising:
- a) determining a concentration of (Granzyme B) GrB in a blood plasma or serum sample from said subject;
- and
- b) comparing said concentration to a corresponding concentration in a control sample, wherein an elevated concentration of GrB is indicative of chronic inflammatory disease.
Dependencies are inferred from the claim text.