Method for predicting and preventing cardiovascular disease
AssigneesUniversity of Rochester, University of Florida
InventorsJacqueline Abranches, José A. Lemos, Robert A. Burne
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Abstract
Disclosed are methods of identifying an individual having a predisposition to the development of a cardiovascular disease, and administering a suitable prophylactic agent to the identified individual to prevent disease. Methods of screening and identifying agents that inhibit bacterial collagen binding protein (CBP)-mediated cell invasion are also disclosed.
Claims15
A method of identifying a subject having a predisposition to development of an infective cardiovascular disease, wherein said subject is in need of a procedure that may result in bacteremia, said method comprising:
- detecting, in a sample obtained from the subject prior to said subject undergoing the procedure that may result in bacteremia, the presence of a bacterium expressing Cnm, wherein said detecting is carried out by an immunoassay, a nucleic acid hybridization assay, or a nucleic acid amplification assay, and
- identifying whether the subject is predisposed to development of an infective cardiovascular disease based on said detecting.
A method of preventing infective cardiovascular disease in a subject comprising:
- detecting, in a sample obtained from the subject prior to said subject undergoing a procedure that may result in bacteremia, the presence of a bacterium expressing Cnm, wherein said detecting is carried out by an immunoassay, a nucleic acid hybridization assay, or a nucleic acid amplification assay;
- administering, based on said detecting, an antibiotic agent to the subject prior to undergoing said procedure, in a dosage suitable for preventing the infective cardiovascular disease in the subject.
A method of preventing infective cardiovascular disease in a subject, said method consisting of:
- selecting a subject (i) in need of a procedure that may result in bacteremia and (ii) having a bacterium expressing Cnm present in a biological sample;
- and
- administering, to the selected subject prior to said procedure, an antibiotic agent in a dosage suitable for preventing infective cardiovascular disease in the subject.
Dependencies are inferred from the claim text.