Immunogenic proteins of Leptospira
AssigneeCornell Research Foundation, Inc.
InventorsYung-Fu Chang, Raghavan U. M Palaniappan
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Abstract
The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.
Claims24
An assay kit for detecting antibodies against Leptospira strains which contains at least one immunologically active purified protein derived from Leptospira interrogans wherein such protein is characterized in that it:
- a. elicits an immunological response from a mammal;
- b. has been prepared by expression in a bacterium other than Leptospira interrogans;
- c. is free of other Leptospira interrogans proteins;
- and
- d. is a protein (i) comprising SEQ ID NO:
- 4, SEQ ID NO:
- 34, or SEQ ID NO:
- 46, or (ii) consisting of at least 9 contiguous amino acids of SEQ ID NO:
- 46;
- which protein reacts with the antibodies present in a test fluid, and wherein said kit has at least one indicator component which detects complexes of immunologically active protein and antibody.
A device comprising a solid surface, wherein at least one immunologically active purified protein derived from Leptospira interrogans is immobilized on the solid surface, wherein such protein is characterized in that it is a protein (i) comprising SEQ ID NO:
- 4, SEQ ID NO:
- 34, or SEQ ID NO:
- 46, or (ii) consisting of at least 9 contiguous amino acids of SEQ ID NO:
- 46.
Dependencies are inferred from the claim text.