Method for diagnosing and treating Crohn's disease
AssigneeLesaffre Et Compagnie
InventorsNicolas Barnich, Arlette Darfeuille-Michaud, Anne-Lise Glasser
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Abstract
The invention concerns an in vitro method for diagnosing Crohn's disease, or for determining predisposition in a person to develop Crohn's disease, by detecting an overexpression of the CD66c receptor in subjects suffering from said disease or at risk. The invention also concerns preventive or curative treatment of Crohn's disease.
Claims11
A method for treating Crohn's disease in a patient suffering from Crohn's disease and having an abnormal overexpression of the CD66c receptor at the ileal level comprising administering to said patient an effective amount of particles carrying one or more mannose units, wherein the particles carrying one or more mannose units inhibit the interaction between an adherent-invasive E. coli (AIEC) and the CD66c receptor expressed at the surface of the enterocytes of said patient, and wherein the particles are living cells, dead cells or inert beads.
A method for inhibiting the interaction between an adherent-invasive E. coli (AIEC) and the CD66c receptor expressed at the surface of the enterocytes of a patient suffering from Crohn's disease and having an overexpression of the CD66c receptor at the ileal level, comprising administering to said patient an effective amount of particles carrying one or more mannose units, and wherein the particles are living cells, dead cells or inert beads.
Dependencies are inferred from the claim text.