Systems and methods for platelet count with clump adjustment
AssigneeBeckman Coulter, Inc.
InventorsShuliang Zhang, Mark Rossman, Jiuliu Lu, John Riley
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Abstract
Embodiments of the present invention encompass automated systems and methods for analyzing platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance and/or light measurement data obtained from the biological sample with an evaluation of platelet conditions in the individual.
Claims28
A hematology system for determining a platelet status in a biological sample, the system comprising:
- a first module configured to determine a platelet clump event and a white blood cell event;
- a second module configured to determine an observed platelet count and a white blood cell concentration;
- and
- a data processing module in connectivity with the first module and the second module, wherein the data processing module comprises a processor and a tangible non-transitory computer readable medium, the computer readable medium programmed with a computer application that, when executed by the processor, causes the processor to determine the platelet status based on the sum of the observed platelet count and a lost platelet count, wherein the lost platelet count comprises a multiplication product of a first factor and a second factor, the first factor based on the platelet clump event and the white blood cell event, and the second factor comprising the white blood cell concentration.
An automated method for determining a platelet status in a biological sample, the method comprising:
- determining, using a first module, a platelet clump event and a white blood cell event;
- determining, using a second module, an observed platelet count and a white blood cell concentration;
- and
- determining, using a data processing module, the platelet status based on the sum of the observed platelet count and a lost platelet count, wherein the lost platelet count comprises a multiplication product of a first factor and a second factor, the first factor based on the platelet clump event and the white blood cell event, and the second factor comprising the white blood cell concentration, further wherein the data processing module comprises a processor and a tangible non-transitory computer readable medium that is programmed with a computer application that, when executed by the processor, causes the processor to determine the platelet status.
Dependencies are inferred from the claim text.