Method of processing target material in a sample

A method of processing a target material in a sample, the method comprising:

• introducing the sample into a first chamber of a microfluidic device, wherein the microfluidic device comprises
• a first chamber with at least one inlet and at least one outlet;
• a second chamber operatively connected with a pressure supply unit;
• and
• an elastic membrane disposed between the first chamber and the second chamber and forming a wall of at least part of the first and second chambers,
• wherein the first chamber comprises or contains a material that binds to a target material,
• applying a positive pressure to the second chamber causing the elastic membrane to be extended toward the first chamber, or applying a negative pressure to the second chamber causing the elastic membrane to be extended towards the second chamber, and
• vibrating the elastic membrane.