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US 9,176,038 B2Granted
Apparatus and method for processing biological material
AssigneeBaxalta Incorporated
InventorsKyungyoon Min, Thomas E. Dudar, James C. Laird
Life of this patent
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Abstract
The application discloses an apparatus and method for processing biological material, including a suspension of cells.
Claims16
An apparatus for concentrating cells in a suspension, the apparatus comprising:
- a first chamber for receiving a suspension including a cell population, the first chamber defined by a first container, said first chamber including a cell concentration zone, said concentration zone configured to receive a concentrated cell population;
- and a second chamber in fluid communication with the first chamber, the second chamber defined by a second container that is physically separable from the first chamber, the second chamber including:
- (i) a housing defining the second chamber as a substantially spherical inner chamber with a substantially spherical inner chamber surface;
- (ii) a port in said housing communicating with the inner chamber and configured to communicate with the first chamber;
- (iii) the port including a resealable closure;
- and
- (iv) the chamber having a cell-receiving pocket positioned generally opposite said port, the cell-receiving pocket depending outwardly from the substantially spherical inner chamber surface,
- said first and second chambers configured to be placed together, as a unit, in a centrifugal force field, wherein upon application of the centrifugal force field said cell-receiving pocket is configured to receive at least a portion of the concentrated cell population from the cell concentration zone of the first chamber.
5 more elements
An apparatus for receiving cells in a suspension, the apparatus comprising:
- a first chamber for receiving a suspension including a cell population, the first chamber defined by a first container, said first chamber including a cell concentration zone, said concentration zone configured to receive a concentrated cell population;
- and a second chamber in fluid communication with the first chamber, the second chamber defined by a second container that is physically separable from the first chamber, the second chamber including:
- (i) a housing defining second chamber as being a substantially spherical inner chamber;
- (ii) a port in the housing communicating with the inner chamber and configured to communicate with the first chamber;
- (iii) the port being the only opening in the housing and including a resealable closure;
- (iv) the inner chamber including a defined gas collection region comprising a volume that is located higher than a lower end of the port when the port is positioned at a top of the chamber,
- said first and second chambers configured to be placed together, as a unit, in a centrifugal force field, wherein upon application of the centrifugal force field said second chamber is configured to receive at least a portion of the concentrated cell population from the cell concentration zone of the first chamber.
4 more elements
An apparatus for receiving cells in a suspension, the apparatus comprising:
- a first chamber for receiving a suspension including a cell population, the first chamber defined by a first container, said first chamber including a cell concentration zone, said concentration zone configured to receive a concentrated cell population;
- and a second chamber in fluid communication with the first chamber, the second chamber defined by a second container that is physically separable from the first chamber, the second chamber including:
- (i) a housing defining the second chamber as being an inner chamber having an inner chamber surface;
- (ii) a port being the only opening in the housing communicating with the inner chamber and configured to communicate with the first chamber;
- (iii) a defined cell collection region in the inner chamber surface positioned generally opposite the port, the cell collection region depending outwardly from the inner chamber surface;
- and
- (iv) a defined gas collection region on the inner chamber surface, the gas collection region comprising a volume that is located higher than a lower end of the port when the port is positioned at a top of the chamber,
- said first and second chambers configured to be placed together, as a unit, in a centrifugal force field, wherein upon application of the centrifugal force field said cell collection region is configured to receive at least a portion of the concentrated cell population from the cell concentration zone of the first chamber.
5 more elements
Dependencies are inferred from the claim text.