Methods of diagnosing endometriosis
AssigneeThe Regents of the University of California
InventorLinda C. Giudice
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Abstract
The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis.
Claims14
A method for detecting the expression of biomarkers in a biological sample comprising endometrial cells or tissue from a human subject, the method comprising:
- detecting in the biological sample expression of a gene or protein, wherein said gene or protein is selected from the group consisting of:
- Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (APOBEC3B);
- DEAD (Asp-Glu-Ala-Asp) box polypeptide (DEAD/H);
- Fibrillin 1 (FBN1);
- Major histocompatibility complex, class II, DOB (HLA-DOB);
- Lactotransferrin (LTF);
- Orosomucoid 2 (ORM2);
- Phospholipase C, beta 4 (PLCB4);
- POM (POM121 homolog, rat) and ZP3 fusion (POMZP3);
- Phosphatidic acid phosphatase, type 2B (PPAP2B);
- and
- Solute carrier family 15, member 2 (SLC15A2).
Dependencies are inferred from the claim text.