Structure with nanopore and apparatus for determining sequences of nucleic acids including the same
AssigneeLG Electronic Inc.
InventorsBongchu Shim, Dami Kim, Seongmoon Cho, Jeankun Oh
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Abstract
Disclosed are a structure with a nanopore and an apparatus for determining sequences of nucleic acids including the structure, the structure including three or more structures having facing surfaces, a plurality of oligonucleotides attached at one ends thereof to the surfaces, and a pore formed between the structures to which the plurality of oligonucleotides are bound, and allowing a pore of a desired size to be precisely formed by adjusting the length of a plurality of oligonucleotides.
Claims10
An apparatus for determining sequences of nucleic acids, characterized by:
- a structure with a nanopore including three or more structures having facing surfaces;
- a plurality of oligonucleotides attached at one ends thereof to the surfaces;
- and
- a pore formed between the structures to which the plurality of oligonucleotides are bound;
- an electrode provided on another surface adjacent to the facing surfaces;
- and
- a tip connected to the electrode, and located in the pore.
A method for manufacturing an apparatus for determining sequences of nucleic acids, the method comprising:
- preparing three or more structures having facing surfaces, an electrode provided on another surface adjacent to the facing surfaces, and a tip connected to the electrode wherein the tip is located in a space where the three or more structures are adjacent to each other;
- attaching one end of a plurality of oligonucleotides to the facing surfaces;
- and
- binding the plurality of oligonucleotides to each other,
- wherein the oligonucleotides attached to the facing surfaces have complementary sequences.
Dependencies are inferred from the claim text.