Chimeric antigen receptor
AssigneesMie University, Takara Bio Inc.
InventorsHiroshi Shiku, Yuki Orito, Junichi Mineno, Sachiko Okamoto, Yasunori Amaishi
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Abstract
Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.
Claims8
A nucleic acid encoding a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain, and at least one intracellular domain, wherein the intracellular domain includes an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR), the intracellular domain further includes a CD3ζ intracellular domain, and the intracellular domain of GITR is arranged on a C-terminal side relative to the CD3ζ intracellular domain,
- wherein a T cell or cell population comprising a T cell expressing the chimeric antigen receptor has an increased cytotoxic activity against a cell having the target antigen on the surface, as compared to a T cell or cell population comprising a T cell expressing a chimeric antigen receptor whose intracellular domain consists of an intracellular domain of CD28 and an intracellular domain of CD3ζ.
A chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain, and at least one intracellular domain, wherein the intracellular domain includes an intracellular domain of a GITR, the intracellular domain further includes a CD3ζ intracellular domain, and the intracellular domain of GITR is arranged on a C end side relative to the CD3ζ intracellular domain,
- wherein a T cell or cell population comprising a T cell expressing the chimeric antigen receptor has an increased cytotoxic activity against a cell having the target antigen on the surface, as compared to a T cell or cell population comprising a T cell expressing a chimeric antigen receptor whose intracellular domain consists of an intracellular domain of CD28 and an intracellular domain of CD3ζ.
Dependencies are inferred from the claim text.