Compositions and methods for inhibiting expression of TMPRSS6 gene
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsDavid Bumcrot, Brian Bettencourt, Ivanka Toudjarska
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Abstract
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6.
Claims37
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of TMPRSS6, wherein said dsRNA comprises a sense strand and an antisense strand, wherein said antisense strand comprises a region of complementarity to a TMPRSS6 RNA transcript comprising a sequence selected from the group consisting of SEQ ID NO:420, SEQ ID NO:112, SEQ ID NO:110, SEQ ID NO:90, and SEQ ID NO:48, and wherein said dsRNA comprises at least one modified nucleotide.
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of TMPRSS6, wherein the dsRNA comprises a sense strand consisting of the sequence of SEQ ID NO:419;
- and an antisense strand consisting of the sequence of SEQ ID NO:420.
Dependencies are inferred from the claim text.