Celluloytic enzymes, nucleic acids encoding them and methods for making and using them

An isolated, synthetic or recombinant polypeptide

• (i) having an amino acid sequence 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or more, or 100% sequence identity to SEQ ID NO:520,
• (ii) having an amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO:519;
• or
• (iii) having an amino acid sequence as set forth in (i) or (ii) and comprising at least one amino acid residue conservative substitution,
• wherein the conservative substitution comprises replacement of an aliphatic amino acid with another aliphatic amino acid;
• replacement of a serine with a threonine or vice versa;
• replacement of an acidic residue with another acidic residue;
• replacement of a residue bearing an amide group with another residue bearing an amide group;
• exchange of a basic residue with another basic residue;
• or, replacement of an aromatic residue with another aromatic residue, or a combination thereof,
• and the aliphatic residue comprises Alanine, Valine, Leucine, Isoleucine or a synthetic equivalent thereof;
• the acidic residue comprises Aspartic acid, Glutamic acid or a synthetic equivalent thereof;
• the residue comprising an amide group comprises Aspartic acid, Glutamic acid or a synthetic equivalent thereof;
• the basic residue comprises Lysine, Arginine or a synthetic equivalent thereof;
• or, the aromatic residue comprises Phenylalanine, Tyrosine or a synthetic equivalent thereof;
• wherein the polypeptide has a heterologous signal sequence or a heterologous pepro sequence, and
• wherein the polypeptide has an oligomerase activity.