Perivascular mesenchymal precursor cell induced blood vessel formation
AssigneeMesoblast, Inc.
InventorsStan Gronthos, Andrew Zannettino
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Abstract
Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 and CD146/MUC18. The perivascular mesenchymal precursor cell is shown to induce neovascularization and improvement in cardiac function. Suitable administration of preparations of the mesenchymal precursor cells are useful for treatment of cardiovascular diseases, cerebrovascular diseases and peripheral vascular diseases.
Claims35
A method of improving cardiac function in a subject suffering from a cardiovascular disease, the method comprising administering to the myocardium or coronary arteries of the subject a population of cells which has been enriched for mesenchymal precursor cells (MPCs) that express the markers STRO-1, CD146, and alpha-smooth muscle actin and do not express CD34, CD45, and glycophorin-A.
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