Postnatal stem cells and uses thereof
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSongtao Shi, Pamela Gehron Robey, Stan Gronthos, Masako Miura
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Abstract
The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
Claims24
An isolated clonal population of human postnatal deciduous dental pulp multipotent stem cells, wherein
- the human postnatal deciduous dental pulp multipotent stem cells are from a postnatal deciduous tooth;
- human postnatal deciduous dental pulp multipotent stem cells in the clonal population differentiate into a neural cell, an adipocyte, or an odontoblast;
- human postnatal deciduous dental pulp multipotent stem cells in the clonal population can proliferate to over 140 population doublings;
- and
- the isolated clonal population of human postnatal deciduous dental pulp multipotent stem cells was expanded ex vivo, wherein the human postnatal deciduous dental pulp multipotent stem cells in the population express CD146.
An isolated human postnatal deciduous dental pulp multipotent stem cell as deposited with the American Type Culture Collection (ATCC) as PTA-11551, wherein the stem cell induces the formation of bone when transplanted in vivo.
A composition comprising a carrier and the cells deposited with the American Type Culture Collection (ATCC) as PTA-11551, wherein the composition induces the formation of bone when transplanted in vivo.
A composition comprising a carrier and a mixed population of human postnatal deciduous dental pulp multipotent stem cells that have been cultured ex vivo, induce formation of bone growth when implanted in vivo, and can proliferate for over 140 population doublings, wherein the human postnatal deciduous dental pulp multipotent stem cells in the population express CD146, and a biocompatible three dimensional carrier.
Dependencies are inferred from the claim text.