Chemosensors for hydrogen sulfide
AssigneeGeorgia State University Research Foundation, Inc.
InventorsHanjing Peng, Binghe Wang
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Abstract
Selective chemosensing agents for hydrogen sulfide are provided. The chemosensing agents can act fast under mild conditions, are chemically stable for long-term storage, are sensitive for detection under near physiological conditions, show a linear concentration-signal relationship within physiologically relevant hydrogen sulfide concentration ranges for easy quantitation, show minimal or no interference by other anions in the blood, and are functional in aqueous solutions and blood plasma.
Claims19
A method of detecting hydrogen sulfide in a sample comprising contacting the sample with a chemosensing agent comprising an azide, wherein the chemosensing agent is represented by the following formula:
- wherein
- F is a fluorophore;
- and
- wherein the azide of the chemosensing agent is reduced by the hydrogen sulfide and the reduction of the azide elicits a change in the maximum emission wavelength of the chemosensing agent, the fluorescence quantum yield of the chemosensing agent, the shape of the emission spectra of the chemosensing agent, the fluorescence lifetime of the chemosensing agent, and combinations thereof.
A chemosensing agent represented by the following formula:
- wherein F is a fluorophore, wherein the fluorophore is selected from the group consisting of xanthene, xanthene derivatives, cyanine, cyanine derivatives, naphthalene, coumarin, coumarin derivatives, oxadiazole derivatives, pyrene, pyrene derivatives, oxazine derivatives, acridine, acridine derivatives, arylmethine derivatives, tetrapyrrole derivatives, fluorene, and fluorene derivatives.
A chemosensing agent represented by Formula I:
- wherein,
- (a) R1 is hydrogen, a substituted or unsubstituted C2-C30 alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group, and
- R2 is hydrogen, a substituted or unsubstituted C1-C30 alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group;
- or
- (b) R1 and R2, together with the nitrogen atom to which they are attached, form a 4- to 8-membered hetercyclic ring.
Dependencies are inferred from the claim text.