Methods for forming stent coatings comprising hydrophilic additives
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsStephen D. Pacetti, Yiwen Tang
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Abstract
A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.
Claims17
A method of fabricating a coating for an implantable medical device comprising:
- providing an implantable medical device;
- preparing a solution comprising at least one hydrophobic polymer comprising a macromolecular chain, at least one hydrophilic polymer comprising a macromolecular chain, and either a solvent or a blend of solvents;
- applying the solution to the implantable medical device;
- and
- removing the solvent or the blend of solvents;
- wherein a physically entangled or intertwined system is formed of the
- macromolecular chains of the hydrophobic polymer and the hydrophilic polymer;
- and
- wherein at least one hydrophobic polymer is selected from the group consisting of polyurethaneureas with a Hildebrand solubility parameter (δ) of less than 10.7 (cal/cm3)1/2.
A method of fabricating a coating for an implantable medical device, comprising forming a coating on the device, the coating comprising a mixture of at least one hydrophobic polymer and at least one hydrophilic polymer;
- wherein the macromolecular chains of the hydrophobic polymer and the hydrophilic polymer form a physically entangled or intertwined system;
- and
- wherein the hydrophobic polymer comprises poly(meth)acrylates
- selected from the group consisting of poly(iso-propyl methacrylate), poly(iso-propyl acrylate), and mixtures thereof.
Dependencies are inferred from the claim text.