Light-activated chimeric opsins and methods of using the same
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKarl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
Claims19
An isolated light-responsive chimeric polypeptide comprising an amino acid sequence having at least 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.
An isolated polynucleotide comprising a nucleotide sequence encoding a light-responsive chimeric polypeptide comprising an amino acid sequence having at least 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.