Monoclonal antibody capable of binding to anexelekto, and use thereof
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTakehisa Kitazawa, Tsukasa Suzuki, Shigehisa Nagahashi, Hajime Miyamoto
Life of this patent
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Abstract
The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.
Claims7
A monoclonal anti-AXL antibody according to any of the following (a) to (b):
- (a) a monoclonal antibody (Ax284) produced from a hybridoma deposited with the International Patent Organism Depositary (IPOD), National Institute of Advanced Industrial Science and Technology (AIST) and assigned Accession No. FERM BP-10857;
- and
- (b) a monoclonal antibody (Ax225) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10854.
A monoclonal anti-AXL antibody that binds to the same epitope bound by either of
- (a) a monoclonal antibody (Ax284) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10857;
- or
- (b) a monoclonal antibody (Ax225) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10854.
A monoclonal anti-AXL antibody that comprises heavy chain CDR1, 2, and 3 amino acid sequences corresponding to SEQ ID NOs:
- 4, 5, and 6, respectively;
- and light chain CDR1, 2 and 3 amino acid sequences corresponding to SEQ ID NOs:
- 8, 9 and 10, respectively.
An isolated hybridoma according to any of the following (a) to (b):
- (a) an isolated hybridoma deposited with IPOD, AIST, and assigned Accession No. FERM BP-10857 (Ax284);
- and
- (b) an isolated hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10854 (Ax225).
A monoclonal anti-AXL antibody that competes for binding to the same epitope bound by either of
- (a) a monoclonal antibody (Ax284) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10857;
- or
- (b) a monoclonal antibody (Ax225) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10854.
Dependencies are inferred from the claim text.