Methods of using an antibody to inhibit WNT-mediated signaling in cancer
AssigneeVanderbilt University
InventorsEthan Lee, Pampee P. Young, Josiane Eid, Robert Carnahan, Curtis Thorne, Kelly Meyers
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Abstract
The present invention is directed to monoclonal antibodies and fragments thereof directed to LRP5/6 that find use in the prevention and treatment of cardiac remodeling and cancer. Also disclosed are methods for using such monoclonal antibodies in the prevention and treatment of such diseases.
Claims18
A method of inhibiting Wnt signaling in a cancer cell with a defect in Adenomatous polyposis coli tumor suppressor (APC) expression or activity comprising contacting said cancer cell with an antibody that binds to low density lipoprotein receptor-related protein 5 and/or 6 (LRP5/6) and has heavy chain complementarity determining regions from SEQ ID NO:
- 2 and light chain complementarity determining regions from SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.