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US 9,175,089 B2Granted
Anti-LGR5 antibodies and immunoconjugates
AssigneeGenentech, Inc.
InventorsJo-Anne Hongo, Weiguang Mao, Paul Polakis, Andrew Polson, Rajesh Vij, Yan Wu, Wei-Ching Liang
Life of this patent
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Abstract
The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
Claims31
An immunoconjugate comprising an isolated antibody that binds to LgR5, wherein the antibody comprises:
- a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 30, HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 31, HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 32, HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 27, HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 28, and HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 29;
- or
- b) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 60, HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 61, HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 62, HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 57, HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 58, and HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 59.
12 more elements
An immunoconjugate comprising:
- a) a VH sequence of SEQ ID NO:
- 6 and a VL sequence of SEQ ID NO:
- 5;
- b) a VH sequence of SEQ ID NO:
- 8 and a VL sequence of SEQ ID NO:
- 7;
- c) a VH sequence of SEQ ID NO:
- 10 and a VL sequence of SEQ ID NO:
- 9;
- d) a VH sequence of SEQ ID NO:
- 12 and a VL sequence of SEQ ID NO:
- 11;
- e) a VH sequence of SEQ ID NO:
- 14 and a VL sequence of SEQ ID NO:
- 13;
- f) a VH sequence of SEQ ID NO:
- 16 and a VL sequence of SEQ ID NO:
- 15;
- g) a VH sequence of SEQ ID NO:
- 18 and a VL sequence of SEQ ID NO:
- 17;
- h) a VH sequence of SEQ ID NO:
- 20 and a VL sequence of SEQ ID NO:
- 19;
- or
- i) a VH sequence of SEQ ID NO:
- 26 and a VL sequence of SEQ ID NO:
- 25;
- and a cytotoxic agent.
26 more elements
Dependencies are inferred from the claim text.