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US 9,175,072 B2Granted
Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen
AssigneeElwha LLC
InventorsRoderick A. Hyde, Wayne R. Kindsvogel
Life of this patent
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Abstract
Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.
Claims38
An isolated recombinant cell line comprising:
- an isolated B lymphocyte cell line including at least one exogenously incorporated nucleic acid, the isolated B lymphocyte cell line capable of expressing the at least one exogenously incorporated nucleic acid encoding at least one exogenously membrane immunoglobulin reactive to a first antigen that is a B lymphocyte-activating antigen and at least one endogenous gene encoding at least one endogenous secreted immunoglobulin reactive to a second antigen from a pathogenic agent.
An isolated recombinant cell line comprising:
- an isolated B lymphocyte cell line including at least one exogenously incorporated nucleic acid, the isolated B lymphocyte cell line capable of expressing the at least one exogenously incorporated nucleic acid encoding at least one exogenous membrane immunoglobulin reactive to a first antigen that is a B lymphocyte-activating antigen and the at least one exogenously incorporated nucleic acid encoding at least one exogenous secreted immunoglobulin reactive to a second antigen from a pathogenic agent.
Dependencies are inferred from the claim text.