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US 9,175,071 B2Granted
Anti-serum albumin binding variants
AssigneeGlaxo Group Limited
InventorsElena De Angelis, Carolyn Enever, Haiqun Liu, Oliver Schon
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Abstract
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-14, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
Claims28
An anti-serum albumin immunoglobulin single variable domain comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 412 (DOM7h-14-10 R108C).
An anti-serum albumin immunoglobulin single variable domain comprising comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 2 (DOM7h-14-18), SEQ ID NO:
- 3 (DOM7h-14-19), SEQ ID NO:
- 4 (DOM7h-14-28), and SEQ ID NO:
- 5 (DOM7h-14-36).
2 more elements
Dependencies are inferred from the claim text.