Neutralizing antibodies to HIV-1 and their use

An isolated human monoclonal antibody, comprising:

• a heavy chain comprising a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR) 1, a HCDR2, and a HCDR3 comprising amino acids 26-33, 51-58, and 97-110 of SEQ ID NO:
• 1, respectively;
• a light chain comprising a light chain variable region comprising a light chain complementarity determining region (LCDR) 1, a LCDR2, and a LCDR3 comprising amino acids 27-30, 48-50, and 87-91 of SEQ ID NO:
• 2, respectively;
• and an Fc region from a different class or subclass of antibody than IgG1;
• wherein the antibody specifically binds to an epitope on a gp120 protein.