Immunoglobulin G Fc region binding polypeptide
AssigneeGE Healthcare Bio-Sciences AB
InventorLars Abrahmsen
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Abstract
An immunoglobulin G Fc region binding polypeptide is provided, consisting of an amino acid sequence selected from i) a variant of Protein A domain or Protein Z and ii) an amino acid sequence which has at least 95% identity thereto. Also provided are methods for producing the polypeptide, compositions comprising the polypeptide, polynucleotides encoding the polypeptide, multimers of the polypeptide, and methods of using the polypeptide.
Claims26
An immunoglobulin G Fc region binding polypeptide, comprising an mamino acid sequence:
- i) X1-([spacer1]-(SEQ ID NO:
- 10)-X17LPX20-
- (SEQ ID NO:
- 11)-X36-(SEQ ID NO:
- 12)-
- X51-(SEQ ID NO:
- 13)-[spacer2])n-CCTERM-1XCTERM
- wherein, independently of each other,
- X1 is P or nothing;
- [spacer1] is an amino acid sequence consisting of 1-3 amino acid residues;
- X17 is any amino acid residue;
- X20 is any amino acid residue;
- X36 is any amino acid residue except for D;
- X51 is any amino acid residue;
- [spacer2] is an amino acid sequence consisting of 0-20 amino acid residues;
- XCTERM is D or nothing;
- and n is 1-4.
The IgG Fc-binding polypeptide an amino acid sequence selected from SEQ ID NO:5-6.
An IgG Fc-binding polypeptide comprising an amino acid sequence selected from SEQ ID NO:1-4.
Dependencies are inferred from the claim text.