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US 9,175,066 B2Granted
Compositions containing HC-HA complex and methods of use thereof
AssigneeTissuetech, Inc.
InventorsScheffer Tseng, Hua He
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Abstract
Disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by TSG-6. Further disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of IαI, wherein the transfer of the heavy chain of IαI is catalyzed by the TSG-6 like protein. Additionally, disclosed herein are methods of manufacturing said complex and methods of use thereof.
Claims7
A method of producing a reconstituted HC•HA (rcHC•HA) complex, comprising
- (a) providing HA Binding Protein (HABP) crosslinked to a stationary support;
- (b) contacting the HABP crosslinked to the stationary support with
- (i) hyaluronan (HA);
- (ii) HC1 and HC2 of IαI;
- and
- (iii) TSG-6;
- and
- (c) incubating for a period of time sufficient to produce rcHC•HA complex.
5 more elements
Dependencies are inferred from the claim text.