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US 9,175,063 B2Granted
Anti-angiogenic agent and methods of using such agent
AssigneeGeorgia State University Research Foundation, Inc.
InventorsZhi-Ren Liu, Jenny J. Yang, Yin Lu
Life of this patent
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Abstract
Anti-angiogenic agents or polypeptides comprising an amino acid segment substantially similar to domain one of CD2 wherein the polypeptide has a β-sheet formed by two segments. Methods of using such agents and polypeptide are also included.
Claims9
A method of reducing angiogenesis in an individual in need of angiogenesis reduction, the method comprising:
- administering to an individual a therapeutically effective dose of a modified CD2 polypeptide derived from human or rat domain one of CD2 polypeptide, the modified CD2 polypeptide having non-wild type characteristics, the non-wild type characteristics including a β-sheet formed by two segments having at least five amino acids alternating between hydrophilicity and hydrophobicity, an anti-parallel fold, an inward-facing hydrophobic surface, and an outward-facing hydrophilic surface.
Dependencies are inferred from the claim text.