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US 9,175,061 B2Granted
Protein conjugates and methods for their preparation
AssigneeNovo Nordisk Health Care AG
InventorFlorencio Zaragoza Dörwald
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Abstract
Reductive amination of peptide-derived aldehydes with anilines or heteroarylamines containing a property-modifying group provides new, hydrolytically stable protein conjugates, suitable for therapy.
Claims11
A conjugated peptide according to formula (I)
- wherein
- Prot is a peptide-derived radical, wherein said peptide-derived radical formed by the formal removal of a hydrogen atom from an amino group (—NH2) of said peptide,
- R1 is arylene or a heteroarylene, optionally substituted with a C1-6-alkyl, halogen, cyano, nitro, hydroxyl, carboxyl, or aryl group;
- R2 is a linker comprising the diradical C(═O)—NH—, and
- R3 is a property-modifying group;
- R4 is hydrogen or C1-6-alkyl;
- R5 is —CH2— or —C(═O)—,
- or pharmaceutically acceptable salts, thereof.
5 more elements
Dependencies are inferred from the claim text.