PEG modified exendin or exendin analog and compositions and use thereof
AssigneeShanghai Benemae Pharmaceutical Corporation
InventorsWenchao Bao, Hongjing Xu, Gang Yu, Yajun Zuo
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Abstract
Exendins or exendin analogs modified by one or more PEG derivatives that may be linked to one or more amino acids of the exendins or exendin analogs are provided. The PEG derivatives may have branched structure set forth in any one of formulas I-IV. Compositions including the PEG derivative modified exendin or exendin analog, methods of making or administering the modified exendin or exendin analog, and various uses thereof are also provided.
Claims11
A PEG modified exendin or exendin analog comprising one or more PEG derivatives linked to one or more amino acids of said exendin or exendin analog, wherein the molecular weight of said one or more PEG derivatives exceeds 20,000 Da, and said one or more PEG derivatives comprise a branched structure set forth in Formula IV below:
- wherein PEG is —O(CH2CH2O)q, q is a positive integer, and Me is a methyl group.
Dependencies are inferred from the claim text.